- 3,715 riders raise $1.26 million
- Top fundraiser: Gordon Gross – $17,690
- Top youth fundraiser: Alexander Grano – $5,236
- Top team: UB Spirit
- The 2006 Extra Mile Club has 192 members.
- New & Notable: The Ride breaks the $1 million mark in this, its 11th year. The 20-mile River Ride makes its debut. Roswell Park’s WJK Park and Gardens is renamed Kaminski Park and Gardens after the late Waldemar Kaminski, a self-made millionaire whose donations underwrote its development in 2000.
